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The Genetic Causes of Male Infertility in Iranian Population; A systematic Review- علل ژنتیکی ناباروری مردان در ایران

Faezeh Azizi1, Mir Davood Omrani2, Mohammad Ali Sadighi Gilani3, Jalil Hosseini*4



1. Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3. Department of Urology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

4. Infertility and Reproductive Health Research Center, Shahid Beheshti Medical University, Tehran, Iran.



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Abstract:

Infertility affects an estimated 15% of couples globally and in Iran, a quarter of cou-ples experiences primary infertility. Males are found to be individually responsible for 20-30% of infertility cases and contribute to 50% of cases totally. When assisted reproductive technologies (ARTs) are used to acquire pregnancy, a sufficient (epi) genetic diagnosis of male infertility (MI) is of main matter to consider if a genetic abnormality will be transmit-ted to offspring. Infertility cen-ters together with Infertility research centers had been founded since 1994 in Iran and many arti-cles from research projects have been published.


keywords: ناباروری مردان - علل ژنتیکی-Iranian infertile men; chromosome abnormalities; Y-chromosome microdeletions; gene mutations; expression and polymorphisms