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Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women ≥38 years old
 Marta Devesa Rosa Tur Ignacio Rodríguez Buenaventura Coroleu Francisca Martínez Nikolaos P Polyzos
Department of Obstetrics, Gynecology and Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain
Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium
Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark
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STUDY QUESTION
Is there any relationship between the number of oocytes retrieved and cumulative live birth rates (CLBRs) in women of advanced age?
SUMMARY ANSWER
CLBRs increase with the number of oocytes retrieved in women of advanced reproductive age up to 41 years old, the added value is minimal in women more than 41 years and futile in women 44 years or older.
WHAT IS KNOWN ALREADY
CLBR is actually the most relevant outcome of IVF from patients’ perspective. There are several studies that have analysed CLBR’s but some of them have included several stimulation cycles, others have not included the frozen embryo transfers (FETs) in their analysis and none has focused on women of advanced reproductive age. We aimed to assess CLBR in women ≥38 years after a single stimulation cycle plus the subsequent frozen embryo transfers.
STUDY DESIGN, SIZE, DURATION
This is a retrospective analysis carried out in a University-affiliated tertiary centre between January 2000 and December 2013. Overall, 4570 infertile women aged ≥38 years who underwent their first cycle in our centre were included.
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 keywords: cumulative live birth rate, advanced reproductive age, ≥38 years, IVF/ICSI, OUTCOME, predictive model |
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