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IUI: review and systematic assessment of the evidence that supports global recommendations
 Ben Cohlen 1,*, Aartjan Bijkerk1, Sheryl Van der Poel2,5, and Willem Ombelet3,4
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| Abstract:
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BACKGROUND: IUI with or without ovarian stimulation (OS) has become a first-line treatment option for many infertile couples, worldwide.
The appropriate treatment modality for couples and their clinical management through IUI or IUI/OS cycles must consider maternal
and perinatal outcomes, most notably the clinical complication of higher-order multiple pregnancies associated with IUI–OS. With a current
global emphasis to continue to decrease maternal and perinatal mortality and morbidity, the World Health Organization (WHO) had
established a multi-year project to review the evidence for the establishment of normative guidance for the implementation of IUI as a
treatment to address fertility problems, and to consider its cost-effectiveness for lower resource settings.
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 keywords: IUI / ovarian stimulation / expectant management / infertility / fertility problems / prevention of multiple pregnancies / assisted reproduction / evidence-based recommendations / gonadotrophins / clomiphene citrate |
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